KMID : 0363220070450010063
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Korean Journal of Dermatology 2007 Volume.45 No. 1 p.63 ~ p.68
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Two Cases of Pyoderma Gangrenosum Associated with Crohn`s Disease
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Jang Hyo-Chan
Park Gun Kim Hee-Jeung Lee Sung-Woo Chung Hyun
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Abstract
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Pyoderma gangrenosum has been described in association with a wide variety of disorders, including Crohn¡¯s disease, ulcerative colitis, myeloproliferative disease, monoclonal gammopathy, and Behcet¡¯s disease. Herein, we report two cases of pyoderma gangrenosum associated with Crohn¡¯s disease. The first case was a 24-year-old female who presented with multiple, necrotizing ulcers on the scalp, which is a rarely affected site. The other case was a 30-year-old female who presented with erythema nodosum on the lower leg initially, and subsequent rapidly-progressive ulcerating lesions then developed at the previous biopsy and intravenous injection sites. In both cases, the colonoscopic findings were consistent with Crohn¡¯s disease. The lesions improved with a combined therapy of systemic steroids, sulfa drugs and topical 0.03% tacrolimus ointment.
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KEYWORD
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Crohn`s disease, Pyoderma gangrenosum
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